| Beacon Medical Group Inc | South Bend | E21 Health Care | $187.6M | 16 |
| Taylor University | Upland | B42Z Education | $186.7M | 11 |
| INDIANA MEMBERS CREDIT UNION | Indianapolis | P20 Human Services | $182.9M | 30 |
| GOODWILL OF CENTRAL & SOUTHERN INDIANA | Indianapolis | J320 Employment | $181.6M | 10 |
| Marian University | Indianapolis | B420 Education | $175.7M | 24 |
| PHYSICIANS HEALTH PLAN OF NORTHERN INDIANA INC | Fort Wayne | — | $172.2M | 27 |
| DEACONESS CLINIC INC | Evansville | E32 Health Care | $170.7M | 27 |
| St Catherine Hospital Inc | East Chicago | E220 Health Care | $169.4M | 10 |
| Purdue Research Foundation | West Lafayette | B110 Education | $169.4M | 12 |
| GLEANERS FOOD BANK OF INDIANA INC | Indianapolis | — | $166.6M | 7 |
| THE LUTHERAN UNIVERSITY ASSOCIATION INC | Valparaiso | B430 Education | $165.5M | 16 |
| Rose-Hulman Institute of Technology | Terre Haute | — | $164.4M | 15 |
| Community Care Network Inc | Munster | E31 Health Care | $152.9M | 12 |
| Community Foundation of Northwest Indiana Inc | Munster | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $144.6M | 35 |
| COOK GROUP HEALTH PLAN TRUST | Bloomington | — | $144.6M | 0 |
| NORTON - KING'S DAUGHTERS' HEALTH INC | Madison | E220 Health Care | $144.1M | 14 |
| Mid Central Operating Engineers Health & | Terre Haute | — | $143.3M | 1 |
| INDIANA LABORERS WELFARE FUND | Terre Haute | — | $143M | 0 |
| University Family Physicians Inc | Indianapolis | — | $138.9M | 1 |
| DEACONESS WOMEN'S HOSPITAL OF SOUTHERN | Newburgh | — | $136.7M | 10 |
| MARGARET MARY COMMUNITY HOSPITAL INC | Batesville | E220 Health Care | $136.3M | 12 |
| The Corporation of Saint Mary's College Notre Dame | Notre Dame | B420 Education | $134.8M | 15 |
| NORTHEASTERN RURAL ELECTRIC | Columbia City | — | $132.2M | 19 |
| THE INDIANAPOLIS FOUNDATION INC | Indianapolis | S20 Community Improvement & Capacity Building | $130M | 6 |
| Centra Credit Union | Columbus | W61 Public & Societal Benefit | $125.4M | 19 |
| BOWEN HEALTH INC FKA THE OTIS R BOWEN | Warsaw | F22 Mental Health & Crisis Intervention | $123.7M | 8 |
| FORUM CREDIT UNION | Indianapolis | W61 Public & Societal Benefit | $122M | 15 |
| SAINT JOSEPH REGIONAL MEDICAL | Mishawaka | E210 Health Care | $121.1M | 23 |
| MERIDIAN HEALTH SERVICES CORP | Muncie | F30Z Mental Health & Crisis Intervention | $120M | 7 |
| CAMERON MEMORIAL COMMUNITY HOSPITAL | Angola | E22Z Health Care | $118.9M | 8 |
| SOUTH CENTRAL INDIANA RURAL | Martinsville | — | $117.1M | 20 |
| Indiana University Health Ball Memorial Physicians Inc | Indianapolis | E20 Health Care | $115.6M | 20 |
| Indiana University Health Bedford Inc | Indianapolis | E20Z Health Care | $114M | 19 |
| UNIVERSITY OF EVANSVILLE | Evansville | B430 Education | $113.1M | 15 |
| INDIANA ORGAN PROCUREMENT ORGANIZATION INC | Indianapolis | E40 Health Care | $112.5M | 21 |
| Interra Credit Union | Goshen | — | $110.7M | 26 |
| HENDRICKS COUNTY RURAL ELECTRIC | Danville | — | $108.3M | 16 |
| LESEA GLOBAL FEED THE HUNGRY INC | South Bend | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $108.1M | 2 |
| BOSMA INDUSTRIES FOR THE BLIND INC | Indianapolis | J300 Employment | $105.3M | 18 |
| WHITLEY MEMORIAL HOSPITAL INC | Columbia City | E220 Health Care | $104.1M | 22 |
| Reid Physician Associates Inc | Richmond | E200 Health Care | $103.2M | 11 |
| INDIANA INSTITUTE OF TECHNOLOGY INC | Fort Wayne | B430 Education | $101.7M | 12 |
| ENDLESS SUCCESS FOUNDATION INC | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $100.4M | 0 |
| GENE B GLICK FAMILY HOUSING | Indianapolis | L20 Housing & Shelter | $96.7M | 1 |
| Culver Educational Foundation | Culver | B250 Education | $96.4M | 8 |
| CENTERSTONE OF INDIANA INC | Bloomington | F31Z Mental Health & Crisis Intervention | $92.5M | 9 |
| Goshen Health System Inc | Goshen | E32Z Health Care | $91.3M | 11 |
| STRADA EDUCATION FOUNDATION INC | Indianapolis | S80 Community Improvement & Capacity Building | $91.3M | 30 |
| Indiana State Council of Roofers | Lafayette | — | $90.3M | 0 |
| HEARTLAND RURAL ELECTRIC MEMBERSHIP CORP | Markle | Y22 Mutual & Membership Benefit | $89.9M | 18 |
