| MARINA KELLEN FRENCH FOUNDATION INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $514.1M | 0 |
| THE BROOKLYN HOSPITAL CENTER | Brooklyn | E220 Health Care | $506.1M | 19 |
| THE MICHAEL J FOX FOUNDATION | New York | H48 Medical Research | $505.3M | 11 |
| THE FORD FOUNDATION | New York | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $502.4M | 22 |
| THE ROCKEFELLER UNIVERSITY | New York | B430 Education | $501M | 20 |
| HIGHLAND HOSPITAL OF ROCHESTER | Rochester | E220 Health Care | $497.7M | 12 |
| Our Lady of Lourdes Memorial Hospital Inc | Binghamton | E22 Health Care | $488.9M | 14 |
| MVHS INC | Utica | E22 Health Care | $485.8M | 11 |
| Mercy Hospital of Buffalo | Buffalo | E220 Health Care | $480.2M | 21 |
| CHAMPLAIN VALLEY PHYSICIANS HOSPITAL | Plattsburgh | E220 Health Care | $469.8M | 16 |
| LONG ISLAND UNIVERSITY | Brookville | — | $466.5M | 19 |
| CATHOLIC MANAGED LONG TERM CARE INC | New York | E60 Health Care | $466.2M | 10 |
| RICHMOND MEDICAL CENTER | Staten Island | E20 Health Care | $461.1M | 19 |
| ARNOT OGDEN MEDICAL CENTER | Elmira | E220 Health Care | $457.1M | 12 |
| THE ANDREW W MELLON FOUNDATION | New York | B82 Education | $450.4M | 15 |
| ELLIS HOSPITAL | Schenectady | E220 Health Care | $444.3M | 10 |
| SAMARITAN HOSPITAL | Troy | E220 Health Care | $441.7M | 16 |
| John T Mather Memorial Hospital | Westbury | E220 Health Care | $436.7M | 20 |
| OPEN SOCIETY INSTITUTE | New York | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $436.3M | 12 |
| UNITED FEDERATION OF TEACHERS | New York | — | $435.8M | 11 |
| FLUSHING HOSPITAL MEDICAL CENTER | Flushing | E220 Health Care | $426.2M | 8 |
| UNITED STATES TENNIS ASSOCIATION INCORPORATED | Purchase | — | $424.6M | 25 |
| North Shore-LIJ Anesthesiology PC | Westbury | E60 Health Care | $424.3M | 13 |
| PHELPS MEMORIAL HOSPITAL ASSOCIATION | Westbury | E220 Health Care | $419.9M | 21 |
| Success Academy Charter Schools - NYC | New York | B29 Education | $417.6M | 5 |
| NYC DISTRICT COUNCIL OF CARPENTERS | New York | — | $416.1M | 7 |
| Wyckoff Heights Medical Center | Brooklyn | E21 Health Care | $415.3M | 13 |
| Albert Einstein College of Medicine | Bronx | B50 Education | $411.4M | 12 |
| The American Jewish Joint Distribution | New York | Q330 International, Foreign Affairs & National Security | $409.8M | 13 |
| INSTITUTE OF INTERNATIONAL EDUCATION INC | New York | Q220 International, Foreign Affairs & National Security | $395.5M | 11 |
| THE NEW YORK PUBLIC LIBRARY | New York | B700 Education | $394.3M | 29 |
| Montefiore Health System Inc | Tarrytown | E19 Health Care | $393.4M | 9 |
| Sisters of Charity Hospital | Buffalo | E220 Health Care | $391.8M | 21 |
| Episcopal Health Services Inc | Garden City | E210 Health Care | $389.9M | 24 |
| THE LEONA M AND HARRY B HELMSLEY | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $385.2M | 8 |
| YESHIVA UNIVERSITY | New York | B430 Education | $382.4M | 14 |
| THE AMERICAN SOCIETY FOR THE PREVENTION | New York | D200 Animal-Related | $379.3M | 14 |
| PLANNED PARENTHOOD FEDERATION OF | New York | E420 Health Care | $378.2M | 11 |
| Montefiore Nyack Hospital | Nyack | E220 Health Care | $378M | 11 |
| THE LEGAL AID SOCIETY | New York | I800 Crime & Legal-Related | $376.6M | 13 |
| NEW YORK-PRESBYTERIAN FUND INC | New York | E120 Health Care | $375.5M | 12 |
| WELLSPRING PHILANTHROPIC FUND INC | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $375M | 5 |
| NOVO FOUNDATION | Hurley | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $373.9M | 2 |
| LOCAL INITIATIVES SUPPORT CORPORATION | New York | S200 Community Improvement & Capacity Building | $373.1M | 52 |
| STEPHEN SILLER TUNNEL TO TOWERS | Staten Island | B82 Education | $373M | 0 |
| LONG ISLAND COMMUNITY HOSPITAL AT | Patchogue | E220 Health Care | $370M | 16 |
| TOURO UNIVERSITY | New York | B420 Education | $367.3M | 29 |
| ITHACA COLLEGE | Ithaca | B420 Education | $358.1M | 28 |
| PHYSICIANS OF UNIVERSITY HOSPITAL PC | Westbury | E30 Health Care | $356.3M | 11 |
| Nuvance Health | Poughkeepsie | E11 Health Care | $352.8M | 16 |
