| ENERGY RESOURCE CENTER | Colorado Springs | L810 Housing & Shelter | $19.6M | 4 |
| The Norwood Foundation | Colorado Springs | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $19.4M | 0 |
| COLORADO REGIONAL HEALTH INFORMATION ORGANIZATION | Denver | W050 Public & Societal Benefit | $19.4M | 4 |
| DENVER ACADEMY INC | Denver | B28Z Education | $19.4M | 7 |
| COLORADO SYMPHONY ASSOCIATION | Denver | A690 Arts, Culture & Humanities | $19.4M | 19 |
| REDHILL FOUNDATION - ROTHBERG FAMILY CHARITY TRUST | Estes Park | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.3M | 0 |
| WEST CENTRAL MENTAL HEALTH CENTER INC DBA SOLVISTA HEALTH | Canon City | F30Z Mental Health & Crisis Intervention | $19.3M | 10 |
| SOCIETY OF FAMILY PLANNING | Denver | S41 Community Improvement & Capacity Building | $19.3M | 1 |
| Rocky Mountain Classical Academy | Colorado Springs | B29 Education | $19.2M | 2 |
| CHARLES SCHWAB FOUNDATION | Lone Tree | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.2M | 0 |
| LA CLINICA TEPEYAC | Denver | E30 Health Care | $19.1M | 9 |
| OWEESTA CORPORATION | Longmont | S20 Community Improvement & Capacity Building | $19.1M | 6 |
| URBAN LAND CONSERVANCY | Denver | S20 Community Improvement & Capacity Building | $18.8M | 8 |
| LA RAZA SERVICES INC | Denver | — | $18.7M | 5 |
| INVESTMENT MANAGEMENT CONSULTANTS ASSOCIATION INC | Greenwood Village | — | $18.7M | 10 |
| SANGRE DE CRISTO HOSPICE & PALLIATIVE CARE | Pueblo | P74Z Human Services | $18.6M | 9 |
| SOCIETY FOR MINING METALLURGY & EXPLORATION (SME) | Englewood | U30C Science & Technology | $18.6M | 8 |
| Lotus School for Excellence | Aurora | — | $18.5M | 9 |
| SRM Legacy Foundation | Colorado Springs | X20 Religion-Related | $18.4M | 2 |
| Vanguard Classical School Inc | Aurora | B29 Education | $18.3M | 2 |
| VAIL VALLEY FOUNDATION | Avon | S410 Community Improvement & Capacity Building | $18.3M | 10 |
| INTERNATIONAL SCHOOL OF DENVER | Denver | B60 Education | $18.3M | 5 |
| SkyView Academy | Highlands Ranch | B29 Education | $18.3M | 2 |
| Nursing and Therapy Services of Colorado | Colorado Springs | E92 Health Care | $18.2M | 10 |
| CROSSPURPOSE | Denver | S21 Community Improvement & Capacity Building | $18.2M | 8 |
| UNITED FOOD AND COMMERCIAL WORKERS INTERNATIONAL UNION 7R LOCAL | Wheat Ridge | — | $17.9M | 38 |
| BAYAUD ENTERPRISES INC | Denver | J330 Employment | $17.8M | 2 |
| OneChild Global | Colorado Springs | Q330 International, Foreign Affairs & National Security | $17.8M | 6 |
| COLORADO FUSION SOCCER CLUB INC | Aurora | N60Z Recreation & Sports | $17.7M | 4 |
| PROSPERITY DENVER FUND | Denver | B82 Education | $17.7M | 1 |
| CENTENNIAL MENTAL HEALTH CENTER INC | Sterling | — | $17.6M | 6 |
| OLATHE COMMUNITY CLINIC INC | Olathe | E32 Health Care | $17.6M | 7 |
| St Anne's Episcopal School Inc | Denver | — | $17.6M | 8 |
| VAIL MOUNTAIN SCHOOL | Vail | B24Z Education | $17.5M | 7 |
| UNITE AMERICA INSTITUTE INC | Denver | W01 Public & Societal Benefit | $17.5M | 0 |
| LATINO COMMUNITY FOUNDATION OF COLORADO INC | Denver | A23 Arts, Culture & Humanities | $17.4M | 1 |
| HOPE ONLINE LEARNING ACADEMY CO-OP | Englewood | B29 Education | $17.3M | 2 |
| KATHERINE AND CHARLES HOVER GREEN HOUSES INC | Longmont | — | $17.3M | 0 |
| USA HOCKEY FOUNDATION | Colorado Springs | — | $17.3M | 3 |
| CHRISTIAN LIVING COMMUNITIES | Englewood | L22 Housing & Shelter | $17.3M | 12 |
| AVENTA CREDIT UNION | Colorado Springs | — | $17.2M | 15 |
| USA Triathlon of Colorado | Colorado Springs | N71 Recreation & Sports | $17.1M | 12 |
| ENGLISH LANGUAGE INSTITUTE IN CHINA | Fort Collins | Q300 International, Foreign Affairs & National Security | $17.1M | 5 |
| FOUNTAIN VALLEY SCHOOL OF COLORADO | Colorado Springs | B250 Education | $17.1M | 6 |
| ASPEN ART MUSEUM | Aspen | A510 Arts, Culture & Humanities | $17M | 2 |
| DENVER COUNTRY CLUB | Denver | — | $16.9M | 9 |
| NATIONAL BOARD OF CHIROPRACTIC EXAMINERS | Greeley | — | $16.8M | 21 |
| COLORADO WEST PSYCHIATRIC HOSPITAL INC | Grand Junction | F31 Mental Health & Crisis Intervention | $16.8M | 0 |
| The Springs Rescue Mission | Colorado Springs | P20 Human Services | $16.7M | 6 |
| MILE HIGH MONTESSORI EARLY LEARNING CENT | Denver | — | $16.6M | 6 |
