| MICHIGAN STATE UNIVERSITY RESEARCH FOUNDATION | East Lansing | B110 Education | $31.7M | 8 |
| MUNSON MEDICAL GROUP | Traverse City | G90 Diseases, Disorders & Medical Disciplines | $31.6M | 12 |
| MCLAREN HEALTH PLAN COMMUNITY | Flint | E31 Health Care | $31.5M | 13 |
| BRONSON AT HOME | Kalamazoo | E92 Health Care | $31.4M | 16 |
| PAUL AND MAXINE FROHRING FOUNDATION INC | Detroit | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $31.4M | 0 |
| PLANNED PARENTHOOD OF MICHIGAN | Ann Arbor | E42 Health Care | $31.2M | 13 |
| PORTER HILLS PRESBYTERIAN VILLAGE INC | Grand Rapids | P75Z Human Services | $31.1M | 10 |
| PIPE FITTERS LOCAL NO 533 HEALTH & WELFARE PLAN | Troy | — | $31M | 2 |
| CHILDREN'S HOSPITAL OF MICHIGAN FOUNDATION | Detroit | E112 Health Care | $31M | 9 |
| BURCHAM HILLS RETIREMENT CENTER II | East Lansing | P750 Human Services | $30.9M | 2 |
| PUBLIC SERVICE CREDIT UNION | Romulus | — | $30.6M | 10 |
| DIVERSIFIED MEMBERS CREDIT UNION | Detroit | — | $30.6M | 11 |
| WEST MICHIGAN PARTNERSHIP FOR CHILDREN | Dorr | P30 Human Services | $30.4M | 3 |
| GOODWILL INDUSTRIES OF WEST MICHIGAN INC | Muskegon | — | $30.3M | 6 |
| LIVING ALTERNATIVES FOR THE DEVELOPMENTALLY DISABLED INC | Dowagiac | P730 Human Services | $30.2M | 3 |
| WEDGWOOD CHRISTIAN SERVICES | Grand Rapids | P200 Human Services | $30.2M | 4 |
| PEOPLE DRIVEN CREDIT UNION | Southfield | — | $30.1M | 12 |
| OAKLAND LIVINGSTON HUMAN SERVICE AGENCY | Pontiac | P200 Human Services | $30.1M | 4 |
| THE WASHTENAW PACE INC | Ypsilanti | E60 Health Care | $30M | 11 |
| RESIDENTIAL OPPORTUNITIES INC | Kalamazoo | P73Z Human Services | $29.9M | 8 |
| EMBERS CREDIT UNION | Marquette | — | $29.9M | 8 |
| MARWOOD MANOR NURSING HOME | Port Huron | — | $29.8M | 8 |
| ASSOCIATION FOR CHILD DEVELOPMENT | East Lansing | P190 Human Services | $29.7M | 1 |
| MICHIGAN STATE BAR FOUNDATION | Lansing | I128 Crime & Legal-Related | $29.6M | 3 |
| INVEST DETROIT FOUNDATION | Detroit | S30 Community Improvement & Capacity Building | $29.6M | 8 |
| ORCHARDS CHILDREN'S SERVICES INC | Southfield | P30Z Human Services | $29.3M | 7 |
| EASTERN MICHIGAN UNIVERSITY FOUNDATION | Ypsilanti | B11 Education | $29.2M | 8 |
| PIPEFITTERS LOCAL NO 636 INSURANCE FUND | Troy | — | $29.2M | 0 |
| SACRED HEART REHABILITATION CENTER INC | Memphis | F220 Mental Health & Crisis Intervention | $29.1M | 4 |
| GOODWILL INDUSTRIES OF GREATER DETROIT | Detroit | J32Z Employment | $29.1M | 4 |
| Faith Hospice | Byron Center | E92Z Health Care | $29M | 7 |
| MICHIGAN HUMANE SOCIETY | Detroit | D200 Animal-Related | $29M | 10 |
| EVANGELICAL HOMES OF MICHIGAN | Saline | P75 Human Services | $28.8M | 8 |
| PAUL OLIVER MEMORIAL HOSPITAL | Traverse City | E220 Health Care | $28.7M | 18 |
| COMMUNITY LIVING NETWORK INC | Ypsilanti | E50 Health Care | $28.7M | 2 |
| Upper Great Lakes Family Health Center | Gwinn | E20 Health Care | $28.6M | 8 |
| THE HOPE FOUNDATION | Ann Arbor | G99Z Diseases, Disorders & Medical Disciplines | $28.6M | 6 |
| REGION IV AREA AGENCY ON AGING INC (WITH FOSTER GRANDPARENTS PROGRAM) | St Joseph | P81Z Human Services | $28.6M | 1 |
| JEWISH FAMILY SERVICE | West Bloomfield | P40Z Human Services | $28.4M | 6 |
| Michigan Carpenters Health Care Fund | Lansing | — | $28M | 4 |
| COMMON GROUND | Bingham Farms | F40Z Mental Health & Crisis Intervention | $27.9M | 7 |
| GRAND RAPIDS COMMUNITY FOUNDATION | Grand Rapids | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $27.9M | 8 |
| BAC of Michigan Health and Welfare Fund | Troy | — | $27.8M | 8 |
| BEAUMONT HEALTH FOUNDATION | Grand Rapids | E21 Health Care | $27.8M | 11 |
| CAPITAL AREA COMMUNITY SERVICES INC | Lansing | — | $27.7M | 7 |
| Cleary University | Howell | B42Z Education | $27.7M | 7 |
| Michigan Advocacy Program | Ypsilanti | I800 Crime & Legal-Related | $27.6M | 10 |
| REGION II COMMISSION ON SERVICES TO THE AGING | Brooklyn | P81Z Human Services | $27.5M | 13 |
| LANSING ECONOMIC AREA PARTNERSHIP | Lansing | S41 Community Improvement & Capacity Building | $27.5M | 4 |
| NORTHWEST MICHIGAN COMMUNITY ACTION | Traverse City | P200 Human Services | $27.4M | 2 |
