| PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE | Philadelphia | B500 Education | $183.5M | 15 |
| DISTRICT COUNCIL 33 HEALTH -WELFARE FUND | Philadelphia | — | $183M | 15 |
| UPMC CARLISLE | Harrisburg | E220 Health Care | $179.5M | 16 |
| ARIA HEALTH PHYSICIAN SERVICES | Philadelphia | E32Z Health Care | $179.4M | 5 |
| KEYSTONE SERVICE SYSTEMS INC | Harrisburg | P730 Human Services | $179.3M | 9 |
| MERAKEY ALLEGHENY VALLEY SCHOOL | Lafayette Hill | P730 Human Services | $178.9M | 10 |
| GROVE CITY COLLEGE | Grove City | B420 Education | $178.5M | 14 |
| PHILADELPHIA HOUSING DEVELOPMENT CORPORA | Philadelphia | L250 Housing & Shelter | $178.2M | 7 |
| LANCASTER GENERAL MEDICAL GROUP | East Petersburg | E31Z Health Care | $177.8M | 17 |
| PNC FOUNDATION | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $177.6M | 0 |
| SUSQUEHANNA UNIVERSITY | Selinsgrove | B420 Education | $174.3M | 12 |
| PHILADELPHIA UNIVERSITY | Philadelphia | B430 Education | $173.3M | 7 |
| Children's Surgical Associates Ltd | Philadelphia | E31Z Health Care | $173.2M | 11 |
| BROTHER'S BROTHER FOUNDATION | Pittsburgh | Q300 International, Foreign Affairs & National Security | $168.5M | 4 |
| ROBERT MORRIS UNIVERSITY | Moon Township | — | $168.4M | 18 |
| GANNON UNIVERSITY | Erie | B430 Education | $165.8M | 15 |
| ARCADIA UNIVERSITY | Glenside | B430 Education | $164.4M | 17 |
| PENN STATE HEALTH LANCASTER MEDICAL CENTER | Hershey | E22 Health Care | $163.5M | 18 |
| NAZARETH HOSPITAL | Newtown Square | E220 Health Care | $161.2M | 12 |
| THE GUTHRIE CLINIC | Sayre | E21 Health Care | $161.1M | 19 |
| LEHIGH VALLEY HOSPITAL - SCHUYLKILL | Allentown | E220 Health Care | $160.9M | 12 |
| PENN STATE HEALTH HAMPDEN MEDICAL CENTER | Hershey | E22 Health Care | $160.3M | 19 |
| THE PITTSBURGH FOUNDATION | Pittsburgh | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $159.1M | 10 |
| WILLOW VALLEY COMMUNITIES | Lancaster | P750 Human Services | $159.1M | 11 |
| Woods Services Inc | Langhorne | P820 Human Services | $158.1M | 13 |
| MELMARK INC | Berwyn | P700 Human Services | $156.8M | 14 |
| CHH Community Health | Philadelphia | E22 Health Care | $151.9M | 20 |
| WILKES UNIVERSITY | Wilkes Barre | B110 Education | $151.9M | 15 |
| RETIREES OF THE GOODYEAR TIRE & RUBBER COMPANY HEALTH CARE TRUST | Pittsburgh | Y43 Mutual & Membership Benefit | $150.1M | 9 |
| OBERKOTTER FOUNDATION | Philadelphia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $150M | 4 |
| MESSIAH UNIVERSITY | Mechanicsburg | B420 Education | $149.7M | 9 |
| MUHLENBERG COLLEGE | Allentown | B420 Education | $149.6M | 13 |
| MERCYHURST UNIVERSITY | Erie | B420 Education | $146.9M | 12 |
| LAW ENFORCEMENT HEALTH BENEFITSINC | Philadelphia | — | $146M | 14 |
| EMPLOYEE BENEFIT TR OF EASTERN PA | Easton | — | $145.3M | 0 |
| YORK COLLEGE OF PENNSYLVANIA | York | B430 Education | $142.7M | 13 |
| DESALES UNIVERSITY | Center Valley | B430 Education | $142.5M | 17 |
| KENCREST SERVICES | Blue Bell | P820 Human Services | $142.2M | 10 |
| ALLEGHENY COLLEGE | Meadville | B420 Education | $141.2M | 11 |
| MORAVIAN UNIVERSITY | Bethlehem | — | $140.6M | 17 |
| GREATER PENNSYLVANIA CARPENTERS MEDICAL PLAN | Pittsburgh | — | $139.7M | 0 |
| Armstrong County Memorial Hospital | Kittanning | E220 Health Care | $138.1M | 13 |
| American Association for Cancer Research Inc | Philadelphia | H300 Medical Research | $137.4M | 9 |
| EASTERN ATLANTIC STATES REGIONAL COUNCIL OF CARPENTERS | Pittsburgh | — | $137.2M | 48 |
| AMERICAN SOCIETY FOR TESTING AND MATERIALS | West Conshohocken | U400 Science & Technology | $134.7M | 30 |
| KENNEDY MEDICAL GROUP PRACTICE PC | Philadelphia | E20 Health Care | $134.7M | 6 |
| GREATER DELAWARE VALLEY SOCIETY OF TRANSPLANT SURGEONS | Philadelphia | H9B Medical Research | $134.5M | 9 |
| CENTRAL PENNSYLVANIA FOOD BANK | Harrisburg | K31Z Food, Agriculture & Nutrition | $132.6M | 5 |
| REACH CYBER CHARTER SCHOOL | Harrisburg | B28 Education | $132.4M | 9 |
| THE ANNENBERG FOUNDATION | Conshohocken | B82 Education | $131.6M | 5 |
