| Houston Museum of Natural Science | Houston | A560 Arts, Culture & Humanities | $82.1M | 13 |
| The Kinkaid School Inc | Houston | B200 Education | $81.5M | 16 |
| Brazos Education Loan Authority Inc | Waco | B82 Education | $80M | 6 |
| Bowie-Cass Electric Cooperative Inc | Douglassville | — | $80M | 15 |
| MULTIPURPOSE ARENA FORT WORTH | Fort Worth | N19 Recreation & Sports | $79.8M | 7 |
| SOUTH TEXAS BLOOD & TISSUE CENTER | San Antonio | E610 Health Care | $79.8M | 7 |
| UNITED HERITAGE CREDIT UNION | Austin | — | $79.7M | 32 |
| RITA BLANCA ELECTRIC COOPERATIVE INC | Dalhart | — | $79.6M | 18 |
| United Way of Greater Houston | Houston | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $79.6M | 11 |
| NEIGHBORHOOD CREDIT UNION | Dallas | — | $79.5M | 16 |
| BARBARA KAUFFMAN WELDER PRIVATE | Victoria | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $79.5M | 3 |
| LIFESCHOOL OF DALLAS | Red Oak | B99Z Education | $79.4M | 11 |
| Letourneau University | Longview | B430 Education | $79.2M | 9 |
| ED RACHAL FOUNDATION | Corpus Christi | X99J Religion-Related | $78.6M | 7 |
| TRELLIS FOUNDATION | Round Rock | P20 Human Services | $78.3M | 3 |
| NATIONAL CAMPUS AND COMMUNITY | Austin | L22 Housing & Shelter | $78.1M | 2 |
| NATIONAL BOY SCOUTS OF AMERICA FOUNDATION | Irving | O41 Youth Development | $77.9M | 8 |
| STATE FAIR OF TEXAS | Dallas | N520 Recreation & Sports | $77.7M | 16 |
| Cook Children's Home Health | Fort Worth | E92 Health Care | $77.5M | 16 |
| Community Action Corporation of South Texas | Alice | P20Z Human Services | $77.2M | 7 |
| TRUST FOR RETIREE MEDICAL DENTAL AND LIFE INSURANCE PLAN OF ARMY AND AIRFOR | Dallas | — | $77M | 0 |
| VICTORIA ELECTRIC COOPERATIVE INC | Victoria | — | $75.9M | 15 |
| The Moody Endowment | Houston | B280 Education | $75.7M | 3 |
| DEAF SMITH ELECTRIC COOPERATIVE INC | Hereford | — | $75.2M | 14 |
| GREENHILL SCHOOL | Addison | B200 Education | $75.1M | 7 |
| FIRSTMARK CREDIT UNION | San Antonio | — | $75.1M | 11 |
| YMCA OF METROPOLITAN DALLAS INC | Coppell | P270 Human Services | $74.8M | 15 |
| ARROW CHILD & FAMILY MINISTRIES | Spring | S50 Community Improvement & Capacity Building | $74.7M | 12 |
| Hendrick Provider Network | Abilene | E32Z Health Care | $74.6M | 26 |
| The University of TexasTexas A&M Investment Management Company | Austin | B43B Education | $74.6M | 24 |
| Texas Health Hospital Mansfield | Mansfield | E22 Health Care | $74.4M | 9 |
| TEXAS A&M RESEARCH FOUNDATION | College Station | B110 Education | $73.7M | 0 |
| OUR LADY OF THE LAKE UNIVERSITY OF SAN ANTONIO | San Antonio | B43 Education | $73.6M | 8 |
| FMH FOUNDATION | Midland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $73.5M | 1 |
| HEART OF TEXAS ELECTRIC COOPERATIVE | McGregor | Y22 Mutual & Membership Benefit | $73.4M | 15 |
| Baylor Research Institute | Dallas | H900 Medical Research | $73.3M | 13 |
| KATHERINE C CARMODY CHARITABLE TUW | Dallas | — | $73.2M | 1 |
| TOYOTA USA FOUNDATION | Plano | — | $72.8M | 0 |
| WORKFORCE SOLUTIONS BORDERPLEX INC | El Paso | J20 Employment | $72.3M | 2 |
| BUCKNER RETIREMENT SERVICES INC | Dallas | L220 Housing & Shelter | $72M | 14 |
| THE 1877 JOURNEY | Little Elm | L20 Housing & Shelter | $71.6M | 1 |
| DELTA DELTA DELTA COLLEGIATE | Dallas | — | $71.2M | 0 |
| WORKSOURCE - GREATER AUSTIN AREA | Austin | J200 Employment | $71.1M | 6 |
| TAYLOR ELECTRIC COOPERATIVE INC | Merkel | — | $70.7M | 17 |
| FEDERATION OF STATE MEDICAL BOARDS OF | Euless | G05 Diseases, Disorders & Medical Disciplines | $70.5M | 24 |
| WE ARE BLOOD | Austin | E61Z Health Care | $70.4M | 11 |
| NAVARRO COUNTY ELECTRIC | Corsicana | — | $70.2M | 16 |
| HEART OF TEXAS COMMUNITY HEALTH CENTER INC | Waco | E22 Health Care | $70.1M | 0 |
| THE GEORGE FOUNDATION | Richmond | — | $70.1M | 6 |
| Alamo Trust Inc (Formerly Alamo Complex Management) | San Antonio | A54 Arts, Culture & Humanities | $69.6M | 6 |
