| PROSIGHT FINANCIAL ASSOCIATION | Chicago | — | $51.5M | 11 |
| MATHER | Evanston | P19 Human Services | $51.3M | 12 |
| YOUTH CONNECTION CHARTER SCHOOL | Chicago | B20 Education | $51M | 8 |
| FRANK E PAYNE AND SEBA B PAYNE FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $50.9M | 4 |
| CORNERSTONE SERVICES INC | Joliet | P800 Human Services | $50.7M | 10 |
| EVANGELICAL RETIREMENT HOMES OF GREATER CHICAGO INC | Schaumburg | P750 Human Services | $50.4M | 10 |
| Francis W Parker School | Chicago | B200 Education | $50.3M | 7 |
| LITTLE CITY FOUNDATION | Inverness | P700 Human Services | $50.1M | 8 |
| CANTIGNY FOUNDATION | Wheaton | — | $50.1M | 16 |
| NATIONAL SAFETY COUNCIL | Itasca | M400 Public Safety, Disaster Preparedness & Relief | $49.9M | 13 |
| Jewish Community Centers of Chicago | Northbrook | P280 Human Services | $49.5M | 9 |
| SCHWAB REHABILITATION HOSPITAL AND CARE NETWORK | Chicago | E220 Health Care | $48.7M | 14 |
| MHNU CORPORATION | Chicago | P40 Human Services | $48.7M | 12 |
| IPC INTERNATIONAL INC | Bannockburn | — | $48.6M | 12 |
| Harrisburg Medical Center Inc | Harrisburg | E220 Health Care | $48.6M | 18 |
| MATHER INVESTMENTS NFP | Evanston | P81 Human Services | $48.4M | 10 |
| FAIRFIELD MEMORIAL HOSPITAL ASSOCIATION | Fairfield | E22Z Health Care | $48.3M | 12 |
| Adler University | Chicago | B5XZ Education | $48.1M | 17 |
| OPPORTUNITY INTERNATIONAL INC D/B/A OPPORTUNITY INTERNATIONAL-US | Chicago | Q320 International, Foreign Affairs & National Security | $47.8M | 9 |
| BENEVOLENT AND PROTECTIVE ORDER OF ELKS | Chicago | — | $47.7M | 6 |
| EGYPTIAN ELECTRIC COOPERATIVE ASSOCIATION | Murphysboro | — | $47.6M | 16 |
| PRAIRIE STATE CONSERVATION COALITION | Springfield | — | $47.5M | 1 |
| VIBRANT CREDIT UNION | Moline | W61 Public & Societal Benefit | $47.3M | 9 |
| UNITED WAY OF METROPOLITAN CHICAGO INC | Chicago | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $47.1M | 12 |
| CHRISTIAN SOCIAL SERVICES OF ILLINOIS | Belleville | P20 Human Services | $47.1M | 9 |
| PAWS CHICAGO | Chicago | D200 Animal-Related | $47M | 8 |
| South Shore Hospital Corporation | Chicago | E220 Health Care | $46.8M | 8 |
| PLYMOUTH PLACE INC | LaGrange Park | P750 Human Services | $46.7M | 8 |
| AMERICAN ACADEMY OF DERMATOLOGY INC | Rosemont | G90 Diseases, Disorders & Medical Disciplines | $46.7M | 31 |
| AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS | Rosemont | G030 Diseases, Disorders & Medical Disciplines | $46.5M | 32 |
| Maryville Academy | Des Plaines | P730 Human Services | $46.5M | 9 |
| UNDERWRITERS LABORATORIES INC | Evanston | W900 Public & Societal Benefit | $46.5M | 31 |
| FOX VALLEY LABORERS HEALTH & WELFARE FND | Elgin | — | $46.3M | 4 |
| GOODWILL INDUSTRIES OF NORTHERN IL AND WI STATELINE AREA INC | Rockford | — | $46.2M | 5 |
| ROCKFORD UNIVERSITY | Rockford | B430 Education | $45.8M | 7 |
| PANA COMMUNITY HOSPITAL ASSOCIATION | Pana | E22 Health Care | $45.8M | 10 |
| ILLINOIS ELECTRIC COOPERATIVE | Winchester | — | $45.8M | 19 |
| Polish National Alliance of the US of NA | Chicago | — | $45.6M | 10 |
| The Resurrection Project | Chicago | L20Z Housing & Shelter | $45.5M | 9 |
| CIRCLE OF SERVICE FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $45.5M | 1 |
| IROQUOIS MEMORIAL HOSPITAL & RESIDENT HOME | Watseka | E22Z Health Care | $45.5M | 9 |
| THE CHICAGO LIGHTHOUSE FOR PEOPLE WHO ARE BLIND OR VISUALLY IMPAIRED | Chicago | P86 Human Services | $45.4M | 8 |
| COVENANT LIVING COMMUNITIES AND SERVICES | Skokie | P750 Human Services | $45.3M | 16 |
| GREATER FAMILY HEALTH | Hoffman Estates | E99 Health Care | $45M | 10 |
| THE CENTER FOR YOUTH AND FAMILY SOLUTIONS | Peoria | P32 Human Services | $44.9M | 11 |
| THE MEMBERS RETIREMENT PLAN | St Charles | — | $44.8M | 2 |
| NATIONAL ASSOCIATION OF BOARDS OF PHARMACY | Mount Prospect | — | $44.6M | 14 |
| SERTOMA STAR SERVICES INC | Chicago Heights | J300 Employment | $44.6M | 4 |
| ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY FOUNDATION | Chicago | H31Z Medical Research | $44.5M | 8 |
| TRUSTEES OF LIQUOR & ALLIED WORKER UNION LOCAL 3 HEALTH AND WELFARE SALES | River Forest | — | $44.5M | 2 |
