| INFINITE LEGACY INC | Baltimore | E65 Health Care | $76.7M | 15 |
| THE HARVEY M MEYERHOFF FUND INC | Baltimore | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $75.4M | 1 |
| AMERICAN SPEECH-LANGUAGE-HEARING ASSOCIATION | Rockville | — | $75.3M | 13 |
| KENNEDY KRIEGER EDUCATION AND COMMUNITY SERVICES INC | Baltimore | S200 Community Improvement & Capacity Building | $74.4M | 14 |
| LUTHERAN WORLD RELIEF INC | Baltimore | Q330 International, Foreign Affairs & National Security | $72.1M | 18 |
| MUNICIPAL EMPLOYEES CREDIT UNION OF BALTIMORE INC | Baltimore | — | $72.1M | 21 |
| SERVICE COORDINATION INC | Frederick | — | $71.9M | 9 |
| Sherman Fairchild Foundation Inc | Chevy Chase | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $71.6M | 10 |
| ALBRIGHT CARE SERVICES | Frederick | P750 Human Services | $71.5M | 12 |
| GOODWILL INDUSTRIES INTERNATIONAL INC | Rockville | N320 Recreation & Sports | $71M | 13 |
| Maryland Family Care Inc | Baltimore | — | $70.9M | 18 |
| MARYLAND LEGAL SERVICES CORPORATION | Baltimore | I80Z Crime & Legal-Related | $70.9M | 2 |
| FISHER HOUSE FOUNDATION INC | Rockville | Z99Z Unknown | $70M | 12 |
| NAF HOTLINE FUND | Annapolis Junction | E194 Health Care | $69.8M | 4 |
| BULLIS SCHOOL | Potomac | B200 Education | $69.7M | 8 |
| Mt Washington Pediatric Hospital Inc | Baltimore | E240 Health Care | $68.6M | 13 |
| ADVENTIST REHABILITATION HOSPITAL OF MARYLAND INC | Gaithersburg | E22 Health Care | $68.4M | 16 |
| HEBREW HOME OF GREATER WASHINGTON INC | Rockville | E91 Health Care | $68M | 9 |
| CHESAPEAKE LIGHTHOUSE FOUNDATION INC | Laurel | B29 Education | $67.6M | 7 |
| THE GOG FOUNDATION INC | Edgewater | H30 Medical Research | $66.1M | 13 |
| AMERICAN SOCIETY OF HEALTH-SYSTEM PHARMACISTS (ASHP) | Bethesda | — | $64.9M | 26 |
| ADVENTIST HEALTHCARE FORT WASHINGTON MEDICAL CENTER INC | Gaithersburg | — | $64.4M | 12 |
| ENTERPRISE COMMUNITY DEVELOPMENT INC | Columbia | L20 Housing & Shelter | $64.1M | 18 |
| THE UNITED WAY OF CENTRAL MARYLAND INC | Baltimore | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $63.9M | 24 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS & PIPE LINE EMPLOYERS H&W FUND | Columbia | — | $63.5M | 0 |
| BROOKE GROVE FOUNDATION INC | Sandy Spring | E910 Health Care | $62.3M | 10 |
| THE MARYLAND SCHOOL FOR THE BLIND | Baltimore | B280 Education | $61.7M | 7 |
| MEDSTAR HEALTH VISITING NURSE ASSOCIATION INC | Calverton | — | $61.3M | 11 |
| Foundation for the National Institutes of Health Inc | North Bethesda | H920 Medical Research | $61M | 13 |
| THE ASSOCIATED JEWISH COMMUNITY FEDERATION OF BALTIMORE INC | Baltimore | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $60.8M | 8 |
| NAACP EMPOWERMENT PROGRAMS INC | Baltimore | R22 Civil Rights, Social Action & Advocacy | $60.6M | 12 |
| BALTIMORE COMMUNITY FOUNDATION INC | Baltimore | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $60.6M | 9 |
| University of Maryland Community Medical Group Inc | Easton | E320 Health Care | $60.1M | 18 |
| NATIONAL CENTER FOR CHILDREN AND FAMILIES | Bethesda | P430 Human Services | $59.6M | 8 |
| HJF MEDICAL RESEARCH INTERNATIONAL INC 7TH FLOOR VODACOM TOWER URSINO ESTATE | Bethesda | G40 Diseases, Disorders & Medical Disciplines | $58.7M | 11 |
| UNIVERSITY OF MARYLAND PHYSICIANS PA | Baltimore | — | $58.6M | 12 |
| CENTER FOR WORKFORCE INCLUSION INC | Silver Spring | P810 Human Services | $58.3M | 8 |
| HEALTH AND WELFARE TRUST FUND FOR IUOE LOCAL 99 & 99A | Baltimore | — | $58.1M | 3 |
| ENOCH PRATT FREE LIBRARY OF BALTIMORE CITY | Baltimore | B71Z Education | $57.3M | 10 |
| INTERNATIONAL UNION OF PAINTERS AND ALLIED TRADES | Hanover | — | $57M | 17 |
| GILMAN SCHOOL INCORPORATED | Baltimore | B250 Education | $56.1M | 7 |
| NATIONAL AQUARIUM INC | Baltimore | D500 Animal-Related | $55.6M | 11 |
| MEBA MEDICAL AND BENEFITS PLAN | Baltimore | — | $55.3M | 14 |
| NATIONAL ASSOCIATION OF COMMUNITY HEALTH CENTERS INC | Bethesda | E32C Health Care | $55.2M | 9 |
| NOTRE DAME OF MARYLAND UNIVERSITY INC | Baltimore | B430 Education | $55.2M | 11 |
| BEHAVORIAL HEALTH SYSTEMS BALTIMORE | Baltimore | F30Z Mental Health & Crisis Intervention | $54.7M | 15 |
| University of Maryland Baltimore Foundation Inc | Baltimore | B110 Education | $53.9M | 2 |
| AMALGAMATED TRANSIT UNION | Silver Spring | — | $53.3M | 32 |
| BOARD OF CHILD CARE OF THE UNITED METHODIST CHURCH INC | Baltimore | P300 Human Services | $53M | 6 |
| THE ARC BALTIMORE INC | Baltimore | P82Z Human Services | $52.8M | 10 |
