| RAYBURN COUNTRY ELECTRIC COOPERATIVE | Rockwall | — | $683M | 18 |
| Baylor Health Care System | Dallas | Y43 Mutual & Membership Benefit | $677.4M | 1 |
| BakerRipley | Houston | P280 Human Services | $635.4M | 15 |
| Scott & White Hospital Round Rock | Dallas | E20 Health Care | $633M | 22 |
| CHRISTUS Good Shepherd Medical Center | Longview | E220 Health Care | $616.1M | 22 |
| Texas Health Physicians Group | Dallas | E990 Health Care | $613.4M | 30 |
| HARMONY PUBLIC SCHOOLS | Houston | B20 Education | $599.4M | 27 |
| Baylor All Saints Medical Center | Dallas | E220 Health Care | $588.6M | 14 |
| FAMILY ENDEAVORS INC | San Antonio | — | $569.6M | 4 |
| United Regional Health Care System | Wichita Falls | E20Z Health Care | $563.6M | 15 |
| Texas Health Presbyterian Hospital Plano | Plano | E22 Health Care | $551.6M | 20 |
| American Bureau of Shipping | Spring | — | $541.5M | 35 |
| Cook Children's Physician Network | Fort Worth | E240 Health Care | $521.6M | 34 |
| Christus Health Southeast Texas | Irving | E220 Health Care | $514.4M | 15 |
| THE BIG 12 CONFERENCE INC | Irving | B124 Education | $510.7M | 19 |
| TEXAS SCOTTISH RITE HOSPITAL FOR CRIPPLED CHILDREN | Dallas | E240 Health Care | $496.2M | 27 |
| CHRONIC DISEASE FUND INC | Frisco | E600 Health Care | $493.9M | 16 |
| ELECTRIC RELIABILITY COUNCIL OF TEXAS | Austin | W800 Public & Societal Benefit | $488M | 28 |
| KIPP Texas Inc | Houston | B24 Education | $484.5M | 16 |
| BLUEFORGE ALLIANCE | Bryan | U40 Science & Technology | $480.9M | 12 |
| ST JOSEPH REGIONAL HEALTH CENTER | Bryan | E22 Health Care | $471.1M | 12 |
| Christus Health Ark-La-Tex | Texarkana | E210 Health Care | $470.6M | 23 |
| Hillcrest Baptist Medical Center | Dallas | E220 Health Care | $455.6M | 16 |
| TRI-COUNTY ELECTRIC COOPERATIVE INC | Aledo | — | $454M | 21 |
| Cook Children's Health Care System | Fort Worth | E210 Health Care | $451.9M | 41 |
| Texas Essential Healthcare Partnerships | Austin | E11 Health Care | $443M | 0 |
| KIMBERLY TETER PRVT BANK EST TR | San Antonio | — | $438.2M | 1 |
| BP CORPORATION NORTH AMERICA INC VEBA | Houston | Y43 Mutual & Membership Benefit | $414.5M | 1 |
| Texas Health Harris Methodist Hospital | Fort Worth | E220 Health Care | $410.7M | 18 |
| EAST TEXAS ELECTRIC COOP | Nacogdoches | — | $406.1M | 30 |
| Baylor Regional Medical Center at | Dallas | E220 Health Care | $403.1M | 16 |
| CHARLES BUTT PHILANTHROPIES | San Antonio | — | $398.5M | 0 |
| Baptist Hospitals of Southeast Texas | Beaumont | E200 Health Care | $380M | 14 |
| STOLLER FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $376.7M | 12 |
| Baylor Regional Medical Center at Plano | Dallas | E22 Health Care | $376.5M | 16 |
| ABILENE CHRISTIAN UNIVERSITY | Abilene | — | $361.6M | 22 |
| Texas Health Harris Methodist Hospital | Bedford | E220 Health Care | $359.6M | 17 |
| TEXAS DOW EMPLOYEES CREDIT UNION | Houston | — | $357.9M | 30 |
| UNITED ELECTRIC COOPERATIVE | Cleburne | Y22 Mutual & Membership Benefit | $353.4M | 25 |
| GUADALUPE VALLEY ELECTRIC COOPERATIVE | Gonzales | Y22 Mutual & Membership Benefit | $344.4M | 23 |
| LEGACY COMMUNITY HEALTH SERVICES | Houston | E30 Health Care | $339.9M | 20 |
| Trinity University | San Antonio | B430 Education | $338.7M | 14 |
| Texas Health Arlington Memorial Hospital | Arlington | E220 Health Care | $337.3M | 0 |
| Barrio Comprehensive Family Health Care Center Inc | San Antonio | E30 Health Care | $337.3M | 12 |
| RALLY CREDIT UNION | Corpus Christi | — | $332.3M | 23 |
| SCHLUMBERGER GROUP HEALTH CARE TRUST | Houston | — | $325M | 1 |
| INTERNATIONAL LEADERSHIP OF TEXAS INC | Richardson | B99 Education | $322M | 8 |
| Scott & White Hospital-College Station | Dallas | E20 Health Care | $321.6M | 21 |
| SOUTHERN HEALTHCARE ALLIANCE | Austin | F990 Mental Health & Crisis Intervention | $318.8M | 0 |
| ST LUKE'S COMMUNITY HEALTH SERVICES | Houston | E20 Health Care | $312.7M | 4 |
