| LIFE FOR RELIEF AND DEVELOPMENT INC | Southfield | Q330 International, Foreign Affairs & National Security | $47.3M | 1 |
| STARFISH FAMILY SERVICES INC | Inkster | P400 Human Services | $47.1M | 6 |
| PLUMBERS & PIPEFITTERS LOCALS 502 & 633 | Troy | — | $47M | 4 |
| GREENPATH INC | Farmington Hills | P51Z Human Services | $46.9M | 12 |
| JOHN E FETZER INSTITUTE INC | Kalamazoo | X99 Religion-Related | $46.8M | 10 |
| HOSPICE CARE OF SOUTHWEST MICHIGAN | Kalamazoo | P74Z Human Services | $46.4M | 11 |
| CNS HEALTHCARE | Novi | F60 Mental Health & Crisis Intervention | $46.4M | 32 |
| My Community Dental Centers Inc | Petoskey | E300 Health Care | $46.1M | 10 |
| DETROIT ATHLETIC CLUB | Detroit | — | $45.9M | 8 |
| GOODWILL INDUSTRIES OF GREATER GRAND | Grandville | J320 Employment | $44.6M | 8 |
| TEAM ONE CREDIT UNION | Saginaw | — | $44.3M | 13 |
| Cure International Inc | Grand Rapids | Q30 International, Foreign Affairs & National Security | $44.1M | 9 |
| BRONSON SOUTH HAVEN HOSPITAL | Kalamazoo | Z99 Unknown | $43.9M | 17 |
| DEARBORN SCHOOLS EMPLOYEE HEALTHCARE PROGRAM VOLUN | Dearborn | Y43 Mutual & Membership Benefit | $43.7M | 0 |
| ALLIANCE CATHOLIC CREDIT UNION | Farmington Hills | — | $43.6M | 9 |
| SPFPA AND PARTICIPATING EMPLOYERS HEALTH AND | Roseville | Y43 Mutual & Membership Benefit | $43.6M | 2 |
| CHRISTIAN FINANCIAL CREDIT UNION | Sterling Heights | — | $43.5M | 8 |
| AMERICAN LIGHTWEIGHT MATERIALS | Detroit | U40 Science & Technology | $43.5M | 12 |
| IBEW LOCAL UNION 347 & NECA | Troy | — | $43.3M | 0 |
| Reliance Community Care Partners | Grand Rapids | E92Z Health Care | $43.2M | 2 |
| OLIVET COLLEGE | Olivet | B420 Education | $43M | 11 |
| MICHIGAN PEER REVIEW ORGANIZATION | Grand Rapids | E00D Health Care | $42.7M | 26 |
| DETROIT 90 90 | Detroit | B02 Education | $42.7M | 8 |
| SPARROW EATON HOSPITAL | Charlotte | E220 Health Care | $42.5M | 0 |
| UNITED METHODIST RETIREMENT COMMUNITIES INC | Chelsea | P75 Human Services | $42.3M | 9 |
| Michigan Masonic Home | Alma | P750 Human Services | $42.1M | 7 |
| TRINITY HEALTH LIFE PENNSYLVANIA INC | Livonia | — | $42.1M | 14 |
| Merit Network Inc | Ann Arbor | W50 Public & Societal Benefit | $41.1M | 24 |
| SCHOOL FINANCE RESEARCH FOUNDATION | Lansing | B99 Education | $41M | 0 |
| THE HERBERT H & GRACE A DOW | Midland | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $40.9M | 3 |
| KALAMAZOO COMMUNITY FOUNDATION | Kalamazoo | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $40.7M | 7 |
| DETROIT SYMPHONY ORCHESTRA INC | Detroit | A690 Arts, Culture & Humanities | $40.7M | 12 |
| TLC COMMUNITY CREDIT UNION | Adrian | — | $40.6M | 8 |
| IRON WORKERS LOCAL 25 HEALTH CARE TRUST | Troy | — | $40.2M | 0 |
| MARLETTE REGIONAL HOSPITAL | Marlette | E22Z Health Care | $40.1M | 7 |
| Herman Miller Inc Benefits Trust | Zeeland | — | $40M | 1 |
| HEGIRA HEALTH INC | Livonia | F22Z Mental Health & Crisis Intervention | $39.7M | 10 |
| CARE RESOURCES | Grand Rapids | E99 Health Care | $39.7M | 0 |
| INTERCARE COMMUNITY HEALTH NETWORK | Bangor | F302 Mental Health & Crisis Intervention | $39.6M | 9 |
| ALPENA ALCONA AREA CREDIT UNION | Alpena | — | $39.6M | 7 |
| DTE ENERGY COMPANY MASTER VEBA TRUST | Detroit | Y43 Mutual & Membership Benefit | $39.2M | 1 |
| ASPIRUS IRON RIVER HOSPITAL & CLINICS | Iron River | E200 Health Care | $39.2M | 26 |
| MICHIGAN EDUCATIONAL CREDIT UNION | Plymouth | — | $39M | 11 |
| THE SENIOR ALLIANCE INC | Dearborn | P81Z Human Services | $38.9M | 4 |
| DETROIT RIVERFRONT CONSERVANCY INC | Detroit | N32 Recreation & Sports | $38.9M | 7 |
| THE GILBERT FAMILY FOUNDATION | Detroit | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $38.5M | 0 |
| GRAND RAPIDS CHRISTIAN SCHOOLS | Grand Rapids | B21Z Education | $38.3M | 5 |
| WORLD MEDICAL RELIEF INCORPORATED | Southfield | Q300 International, Foreign Affairs & National Security | $38M | 1 |
| LIFE CIRCLES | Muskegon | P80 Human Services | $37.8M | 7 |
| CENTER FOR FAMILY HEALTH | Jackson | E30Z Health Care | $37.8M | 11 |
