| THE J DAVID GLADSTONE INSTITUTES | San Francisco | H900 Medical Research | $119.2M | 17 |
| Young Mens Christian Association of San Francisco | San Francisco | P270 Human Services | $119.2M | 23 |
| RIVER SPRINGS CHARTER SCHOOL INC | Temecula | B29 Education | $118.3M | 12 |
| MOUNT SAINT MARY'S UNIVERSITY | Los Angeles | B430 Education | $117.8M | 13 |
| ALLIANCE OF NONPROFITS FOR INSURANCE | Santa Cruz | Y20 Mutual & Membership Benefit | $117.7M | 3 |
| SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | La Jolla | H920 Medical Research | $117.2M | 12 |
| PLANNED PARENTHOOD LOS ANGELES | Los Angeles | E420 Health Care | $117.2M | 8 |
| GATEWAY COMMUNITY CHARTERS | McClellan | B29 Education | $117.1M | 7 |
| LIFEMOVES | Santa Clara | — | $117M | 7 |
| Child Action Inc | Rancho Cordova | P30J Human Services | $117M | 10 |
| MASONIC HOMES OF CALIFORNIA | San Francisco | P750 Human Services | $116.6M | 18 |
| BRIGHT STAR SCHOOLS | Los Angeles | B29 Education | $116.4M | 8 |
| THE SCHMIDT FAMILY FOUNDATION | Palo Alto | B82 Education | $116.3M | 1 |
| CATALYST FAMILY INC | Morgan Hill | B210 Education | $115.9M | 18 |
| The Chicago School - California Inc | Los Angeles | — | $115.9M | 15 |
| OPEN DOOR COMMUNITY HEALTH CENTERS | Arcata | E32 Health Care | $115.5M | 7 |
| THE ASIA FOUNDATION | San Francisco | Q300 International, Foreign Affairs & National Security | $115.3M | 15 |
| UNIVERSITY ENTERPRISES INC | Sacramento | B114 Education | $115.2M | 21 |
| UNIVERSITY OF MASSACHUSETTS GLOBAL | Aliso Viejo | B40 Education | $115M | 11 |
| CONSTRUCTION LABORERS VACATION TRUST FOR | Covina | — | $114.8M | 7 |
| 10100 GROWTH FOUNDATION | Menlo Park | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $114.6M | 0 |
| Los Angeles Firemen's Relief Association | Los Angeles | — | $114.3M | 21 |
| Community Action Partnership of | San Luis Obispo | — | $114.3M | 6 |
| LUCILE PACKARD FOUNDATION FOR CHILDREN'S | Palo Alto | E110 Health Care | $114M | 11 |
| Samuel Merritt University | Oakland | B500 Education | $113.9M | 15 |
| GOODWILL INDUSTRIES OF ORANGE COUNTY | Santa Ana | J320 Employment | $113.4M | 12 |
| Scripps College | Claremont | B420 Education | $113.4M | 16 |
| THE ELI AND EDYTHE BROAD FOUNDATION | Los Angeles | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $113M | 1 |
| FINANCIAL PARTNERS CREDIT UNION | Downey | — | $113M | 44 |
| HOAG HOSPITAL FOUNDATION | Newport Beach | E112 Health Care | $112.9M | 10 |
| Young Men's Christian Association of Metropolitan Los Angeles | Los Angeles | P270 Human Services | $112.2M | 11 |
| CHILDREN'S HOSPITAL AT MISSION | Orange | E24Z Health Care | $111.4M | 10 |
| INTERNEWS NETWORK | Arcata | A320 Arts, Culture & Humanities | $111.3M | 8 |
| CAL POLY CORPORATION | San Luis Obispo | B43 Education | $111.2M | 15 |
| SEQUOIA LIVING INC | San Francisco | P750 Human Services | $111M | 18 |
| SAC HEALTH SYSTEM | San Bernardino | E32 Health Care | $110.8M | 12 |
| MERIWEST CREDIT UNION | San Jose | W610 Public & Societal Benefit | $110.4M | 17 |
| SUTTER COAST HOSPITAL | Sacramento | E220 Health Care | $110.4M | 8 |
| Jacobs & Cushman San Diego Food Bank | San Diego | K31 Food, Agriculture & Nutrition | $110.3M | 7 |
| CONCORDIA UNIVERSITY IRVINE | Irvine | B430 Education | $109.6M | 13 |
| Adventist Health Delano | Delano | E220 Health Care | $109.1M | 22 |
| KQED INC | San Francisco | A300 Arts, Culture & Humanities | $108.9M | 19 |
| SEMI | Milpitas | — | $108.9M | 12 |
| VISTA COMMUNITY CLINIC | Vista | E320 Health Care | $108.8M | 8 |
| Pitzer College | Claremont | B420 Education | $108.5M | 17 |
| SIERRA CLUB FOUNDATION | Oakland | C300 Environment | $108.2M | 7 |
| LOW INCOME INVESTMENT FUND | San Francisco | L820 Housing & Shelter | $108M | 12 |
| CARPENTERS VACATION HOLIDAY AND SICK | Oakland | — | $107.8M | 4 |
| BAY AREA COMMUNITY HEALTH | Fremont | — | $107.7M | 7 |
| CALIFORNIA COLLEGE OF THE ARTS | San Francisco | B420 Education | $107.2M | 11 |
