| PETER & JERI DEJANA FOUNDATION | Port Washington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $302.3M | 0 |
| PLAINVIEW HOSPITAL C/O NORTHWELL HEALTH INC | Westbury | E20 Health Care | $299.5M | 20 |
| ENVIRONMENTAL DEFENSE FUND INCORPORATED | New York | C600 Environment | $298.7M | 13 |
| 1199SEIU GREATER NEW YORK BENEFIT FUND | New York | — | $297.6M | 4 |
| SUN RIVER HEALTH INC | Peekskill | E320 Health Care | $296.6M | 10 |
| CAPITAL AREA SCHOOLS HEALTH INSURANCE CONSORTIUM | Scotia | — | $295.8M | 0 |
| HUDSON VALLEY HOSPITAL CENTER | Cortlandt Manor | E220 Health Care | $295.6M | 20 |
| NEW YORK HOTEL TRADES COUNCIL & HOTEL ASSOCIATION OF NEW YORK HEALTH CENTER IN | New York | Y20 Mutual & Membership Benefit | $294.4M | 37 |
| SKIDMORE COLLEGE | Saratoga Springs | B420 Education | $292.6M | 21 |
| ALBANY MED HEALTH SYSTEM | Albany | E21 Health Care | $292.6M | 14 |
| MUNICIPAL CREDIT UNION | New York | — | $291.3M | 26 |
| NATIONAL BASKETBALL PLAYERS ASSOCIATION | New York | — | $291M | 9 |
| SB Clinical Practice Management Plan Inc | Stony Brook | E99 Health Care | $290.2M | 18 |
| NEW YORK STATE INDUSTRIES FOR THE DISABLED INC | Albany | — | $288.9M | 6 |
| ST PETER'S HEALTH PARTNERS MEDICAL ASSOCIATES PC | Albany | E31 Health Care | $288.3M | 33 |
| DUTCHESS EDUCATIONAL HEALTH INSURANCE CONSORTIUM | Poughkeepsie | — | $288.2M | 0 |
| St Luke's Cornwall Hospital | Newburgh | E220 Health Care | $284.4M | 14 |
| New York University in Abu Dhabi Corp | New York | B11 Education | $284.1M | 27 |
| Metropolitan Opera Association Inc | New York | A6A0 Arts, Culture & Humanities | $284M | 12 |
| THE VISITING NURSE ASSOCIATION OF CENTRAL NEW YORK | Syracuse | E92Z Health Care | $283.4M | 11 |
| NEW YORK QUEENS MEDICINE & SURGERY PC | Flushing | E31 Health Care | $281.9M | 7 |
| THE AYCO CHARITABLE FOUNDATION | Cohoes | T300 Philanthropy, Voluntarism & Grantmaking Foundations | $278M | 0 |
| LABOR-MANAGEMENT HEALTHCARE FUND | Cheektowaga | Y43 Mutual & Membership Benefit | $277.9M | 1 |
| THE EPISCOPAL CHURCH CLERGY AND EMPLOYEES BENEFIT TRUST | New York | — | $277.4M | 1 |
| Services for the Underserved Inc | New York | — | $275.9M | 9 |
| ST CHARLES HOSPITAL CORP | Port Jefferson | E220 Health Care | $272.7M | 10 |
| PUBLIC HEALTH SOLUTIONS | New York | H00J Medical Research | $271.2M | 9 |
| Teachers College Columbia University | New York | B500 Education | $267.7M | 16 |
| ST CATHERINE OF SIENA MEDICAL CENTER | Smithtown | E20 Health Care | $267.2M | 12 |
| PEF ISRAEL ENDOWMENT FUNDS INC | New York | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $266.7M | 2 |
| CONSUMER REPORTS INC | Yonkers | W900 Public & Societal Benefit | $266.1M | 14 |
| VISITING NURSE SERVICE OF NEW YORK HOME CARE II | New York | E920 Health Care | $263M | 10 |
| LEBANESE AMERICAN UNIVERSITY | New York | B430 Education | $262.2M | 25 |
| PROJECT ORBIS INTERNATIONAL INC | New York | Q300 International, Foreign Affairs & National Security | $259.2M | 13 |
| BREAKTHROUGH T1D | New York | G800 Diseases, Disorders & Medical Disciplines | $258.1M | 15 |
| COLD SPRING HARBOR LABORATORY | Cold Spring Harbor | U500 Science & Technology | $258M | 12 |
| MASON TENDERS' DISTRICT COUNCIL WELFARE FUND | New York | Y43 Mutual & Membership Benefit | $257.4M | 5 |
| SUNSET PARK HEALTH COUNCIL INC | Brooklyn | E80 Health Care | $255.6M | 13 |
| NEW YORK INDEPENDENT SYSTEM OPERATOR INC | Rensselaer | W800 Public & Societal Benefit | $255.3M | 36 |
| SCO FAMILY OF SERVICES | Garden City | P20 Human Services | $253.3M | 12 |
| YOUNG ADULT INSTITUTE INC | New York | P82 Human Services | $253.2M | 7 |
| THE GOTTESMAN FUND | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $252.9M | 0 |
| TRUSTEES OF UNION COLLEGE IN THE TOWN OF SCHENECTADY IN THE STATE OF NEW YORK | Schenectady | B420 Education | $251.3M | 22 |
| Nuvance Health Medical Practice PC | Poughkeepsie | E210 Health Care | $247.3M | 23 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | Menands | F050 Mental Health & Crisis Intervention | $246.7M | 13 |
| UNITED CEREBRAL PALSY ASSOCIATIONS OF NEW YORK STATE INC | New York | G200 Diseases, Disorders & Medical Disciplines | $243.5M | 9 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF GREATER NEW YORK | New York | P270 Human Services | $241.4M | 24 |
| HITACHI AMERICA LTD HEALTH AND WELFARE | Rye Brook | — | $240.2M | 0 |
| GLEN COVE HOSPITAL C/O NORTHWELL HEALTH INC | Westbury | E20 Health Care | $239.8M | 20 |
| THE ROCKEFELLER FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $238.1M | 19 |
