| ACTS Retirement-Life Communities Inc | Fort Washington | P750 Human Services | $577.2M | 33 |
| Highmark Health | Pittsburgh | E21 Health Care | $568.3M | 20 |
| EXCELA HEALTH GROUP | Greensburg | — | $550M | 13 |
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | Pittsburgh | B430 Education | $543.3M | 26 |
| TOWER HEALTH | Reading | E220 Health Care | $531.6M | 21 |
| COMMUNITY MEDICAL CENTER | Danville | E220 Health Care | $527.4M | 13 |
| Pinnacle Health Medical Services | Harrisburg | E220 Health Care | $522.6M | 15 |
| ROBERT PACKER HOSPITAL | Sayre | E220 Health Care | $517.7M | 14 |
| UPMC | Pittsburgh | E220 Health Care | $496.7M | 0 |
| The Devereux Foundation | Villanova | G050 Diseases, Disorders & Medical Disciplines | $494.2M | 24 |
| JEFFERSON UNIVERSITY PHYSICIANS | Philadelphia | B110 Education | $486.5M | 6 |
| GCU | Beaver | X22 Religion-Related | $486.4M | 23 |
| MOUNT NITTANY MEDICAL CENTER | State College | E220 Health Care | $482.1M | 17 |
| CHESTER COUNTY HOSPITAL | West Chester | E220 Health Care | $479.3M | 18 |
| PENNSYLVANIA STATE EMPLOYEES CREDIT UNION | Harrisburg | — | $468.7M | 22 |
| CHAMBERSBURG HOSPITAL | York | E220 Health Care | $467.4M | 21 |
| ALLEGHENY COUNTY SCHOOLS HEALTH | Wexford | — | $459.8M | 0 |
| MAIN LINE HEALTHCARE | Newtown Square | E300 Health Care | $459.6M | 34 |
| St Clair Health Corporation Group Return | Pittsburgh | — | $456.4M | 17 |
| GUTHRIE MEDICAL GROUP PC | Sayre | E320 Health Care | $453.2M | 12 |
| ST LUKE'S HOSPITAL ANDERSON CAMPUS | Allentown | E20 Health Care | $442.6M | 2 |
| VALLEY MEDICAL FACILITIES INC | Sewickley | E220 Health Care | $434.1M | 15 |
| THE PEW MEMORIAL TRUST | Philadelphia | — | $428.6M | 1 |
| LEHIGH VALLEY HOSPITAL - POCONO | Allentown | E220 Health Care | $426M | 14 |
| SAINT JOSEPH'S UNIVERSITY | Philadelphia | B42 Education | $424.6M | 16 |
| COMMONWEALTH CHARTER ACADEMY CHARTER | Harrisburg | B280 Education | $420.8M | 8 |
| CHILDREN'S HEALTH CARE ASSOCIATES INC | Philadelphia | — | $412.9M | 22 |
| ST MARY MEDICAL CENTER | Langhorne | E220 Health Care | $409.6M | 15 |
| PROJECT MANAGEMENT INSTITUTE | Newtown Square | S41 Community Improvement & Capacity Building | $392M | 13 |
| Bucknell University | Lewisburg | B430 Education | $379M | 29 |
| THE CHILDREN'S HOSPITAL OF PHILADELPHIA | Philadelphia | E110 Health Care | $377.6M | 6 |
| HOLY REDEEMER HEALTH SYSTEM | Huntingdon Valley | E220 Health Care | $370.8M | 14 |
| DOYLESTOWN HOSPITAL | Doylestown | E220 Health Care | $360.7M | 16 |
| GETTYSBURG HOSPITAL | York | E220 Health Care | $357.4M | 18 |
| Temple Faculty Practice Plan Inc | Philadelphia | E60 Health Care | $355M | 21 |
| CARING PEOPLE ALLIANCE | Philadelphia | I20 Crime & Legal-Related | $351.9M | 5 |
| ST JOSEPH REGIONAL HEALTH NETWORK | Hershey | E20 Health Care | $351.3M | 22 |
| NORTHEAST PENNSYLVANIA CENTER FOR | Scranton | P8XZ Human Services | $349.1M | 5 |
| STC HEALTHCARE PARTNERS LLC | Reading | E20 Health Care | $347.6M | 7 |
| Capital Area Behavioral Health | Harrisburg | E012 Health Care | $345.6M | 2 |
| SOUTHWEST BEHAVIORAL HEALTH MANAGEMENT | New Castle | E02 Health Care | $339.9M | 2 |
| EASTERN ATLANTIC STATES CARPENTERS | Philadelphia | — | $332.9M | 6 |
| The American Oncologic Hospital | Philadelphia | E240 Health Care | $329.4M | 14 |
| NATIONAL SLOVAK SOCIETY OF THE USA | Canonsburg | — | $325.2M | 17 |
| RESOURCES FOR HUMAN DEVELOPMENT INC | Philadelphia | P200 Human Services | $316.9M | 19 |
| BUTLER HEALTHCARE PROVIDERS | Butler | E220 Health Care | $311.7M | 17 |
| EPHRATA COMMUNITY HOSPITAL | York | E220 Health Care | $310.1M | 17 |
| PENN STATE HEALTH HOLY | Hershey | E20 Health Care | $309.8M | 20 |
| AMERICAN ELECTRIC POWER SYSTEM EMPLOYEES | Pittsburgh | — | $308.9M | 0 |
| PUBLIC HEALTH MANAGMENT CORPORATION | Philadelphia | F21Z Mental Health & Crisis Intervention | $292.8M | 9 |
