| AMERICAN ELECTRIC POWER SYSTEM EMPLOYEES | Pittsburgh | — | $308.9M | 0 |
| ELWYN OF PENNSYLVANIA AND DELAWARE | Elwyn | P820 Human Services | $304.6M | 15 |
| CLINICAL CARE ASSOCIATES OF THE UNIVERSITY OF PENNSYLVANIA HEALTH SYSTEM | Bala Cynwyd | E300 Health Care | $293.1M | 16 |
| Public Health Management Corporation | Philadelphia | F21Z Mental Health & Crisis Intervention | $291M | 9 |
| Riddle Memorial Hospital | Radnor | E220 Health Care | $286.9M | 11 |
| Temple University Health System Inc | Philadelphia | B19 Education | $283.2M | 24 |
| GRAND VIEW HOSPITAL | Sellersville | E22 Health Care | $283M | 16 |
| GEISINGER-LEWISTOWN HOSPITAL | Danville | E220 Health Care | $282M | 19 |
| EVANGELICAL COMMUNITY HOSPITAL | York | E220 Health Care | $280.1M | 19 |
| University of Scranton | Scranton | B430 Education | $278.9M | 18 |
| PHI GROUP RETURN | Dillsburg | — | $278.6M | 21 |
| UPMC Washington | Washington | E220 Health Care | $276.7M | 16 |
| MEADVILLE MEDICAL CENTER | Meadville | E220 Health Care | $271.3M | 11 |
| WIDENER UNIVERSITY | Chester | B430 Education | $267.4M | 13 |
| DELAWARE COUNTY PUBLIC SCHOOLS HEALTHCARE TRUST | Morton | Y20 Mutual & Membership Benefit | $265.8M | 0 |
| Sun Coast Nursing Centers Inc | Bala Cynwyd | E90 Health Care | $265M | 9 |
| MASONIC VILLAGES OF THE GRAND LODGE OF PENNSYLVANIA | Elizabethtown | L50 Housing & Shelter | $263.4M | 23 |
| LAFAYETTE COLLEGE | Easton | B420 Education | $262.5M | 16 |
| ST LUKE'S HOSPITAL MONROE CAMPUS | Allentown | E22 Health Care | $260.3M | 2 |
| JOHN TEMPLETON FOUNDATION | West Conshohocken | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $258.7M | 17 |
| BRYN MAWR COLLEGE | Bryn Mawr | B420 Education | $254.6M | 17 |
| PENNSYLVANIA LIFE & HEALTH INSURANCE GUARANTY ASSOCIATION | Bala Cynwyd | — | $250.6M | 1 |
| DICKINSON COLLEGE | Carlisle | B420 Education | $244.5M | 19 |
| MERCY CATHOLIC MEDICAL CENTER OF SOUTHEASTERN PENNSYLVANIA | Newtown Square | E220 Health Care | $236.4M | 14 |
| INDIANA REGIONAL MEDICAL CENTER | Indiana | E22 Health Care | $235.2M | 16 |
| MAIN LINE SERVICES | Radnor | — | $234.4M | 20 |
| UPMC MEMORIAL | Harrisburg | E220 Health Care | $233.9M | 16 |
| ST LUKE'S WARREN HOSPITAL INC | Allentown | E220 Health Care | $233.5M | 11 |
| UPMC HANOVER | Harrisburg | E220 Health Care | $233.2M | 16 |
| THE CAHOUET FOUNDATION TR | Pittsburgh | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $230.7M | 1 |
| COMMUNITY SERVICES FOR CHILDREN INC | Allentown | B22Z Education | $230.5M | 12 |
| UPMC PINNACLE | Harrisburg | E220 Health Care | $230M | 16 |
| CONSTELLATION EMPLOYEES BENEFIT TRUST | Kennett Square | Y43 Mutual & Membership Benefit | $228.8M | 1 |
| GETTYSBURG COLLEGE | Gettysburg | B420 Education | $228.8M | 18 |
| THE PENNSYLVANIA CYBER CHARTER SCHOOL | Midland | B29 Education | $223.6M | 13 |
| Northeast Behavioral Health Care Consort | Moosic | F80 Mental Health & Crisis Intervention | $222.2M | 5 |
| LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE | Erie | B500 Education | $222.1M | 12 |
| TOWER HEALTH MEDICAL GROUP | Reading | — | $217.6M | 13 |
| RICHARD KING MELLON FOUNDATION | Ligonier | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $210.9M | 5 |
| EMPLOYEE BENEFIT TRUST OF BANK OF | Pittsburgh | Y43 Mutual & Membership Benefit | $206.4M | 0 |
| LINCOLN BENEFIT TRUST | New Oxford | — | $205.6M | 1 |
| CORPORATION OF HAVERFORD COLLEGE | Haverford | B420 Education | $205M | 19 |
| Uniontown Hospital | Uniontown | E20 Health Care | $204.2M | 16 |
| GEISINGER HEALTH | Danville | E110 Health Care | $202.8M | 20 |
| FRANKLIN & MARSHALL COLLEGE | Lancaster | B420 Education | $201.4M | 18 |
| LEHIGH VALLEY HOSPITAL-HAZLETON | Allentown | E220 Health Care | $198.9M | 14 |
| TRUMARK FINANCIAL CREDIT UNION | Fort Washington | — | $198.1M | 26 |
| National Board of Medical Examiners | Philadelphia | E030 Health Care | $189.8M | 27 |
| MERAKEY PENNSYLVANIA | Lafayette Hill | F20 Mental Health & Crisis Intervention | $189.7M | 12 |
| ST LUKE'S QUAKERTOWN HOSPITAL | Allentown | E22Z Health Care | $189.5M | 6 |
